QuickGene Update 1.0.1

The first update after big QuickGene's release, just over a month ago, introduces some smaller changes and improvements. The most popular request was the ability to disable translation of the complement strand, which has been added as a view option. The enzyme database has also received a major overhaul, including the extensive changes to the New England Biolabs buffer recommendations and introducing the EcoRI buffer activities for all NEB enzymes.

Another useful new function is the intelligent annotation of features when opening GenBank files. You have likely encountered the problem of opening annotated GenBank files only to see all the features named "CDS" or "gene". This is common for files that have been saved or modified in programs that save the name incorrectly. QuickGene uses the correct names and, when these can't be found, deduces names from other specifications of features, attempting to provide you with the most descriptive annotations possible.

In the meantime, some bigger, research-enhancing features are approaching completion which you can expect to see next month's update. Stay tuned!

New features

• In-line search results can now easily be converted to features by double-clicking on them.


• Translation of the complement strand can now be disabled in the view options.

Changes

• Updated the enzyme database, including major changes to the NEB buffer activities and recommendations.


• Improved security and reliability when activating and updating QuickGene.


• Updating QuickGene now shows its progress.


• Improved naming of features when opening GenBank files.


• Fixed the base pair location in the status bar to update when clicking on enzyme tooltips.


• Fixed certain cases where composite features could cause problems in QGProject files.

QuickGene 1.0 Launched!

Today's the big day! Twenty-two months after starting development, seventeen months after founding CrimsonBase and 365 days after QuickGene's first careful steps into the world, we're very proud to take the "beta" sticker off, making QuickGene 1.0 a fact.

This important milestone was reached thanks to the coordinated efforts of the entire team and in no small part to the hundreds of beta testers who offered constant encouragement and over 500 ideas. All those suggestions have proved invaluable, constantly reshaping and perfecting our plans, and we certainly aim to continue and expand this collaboration. We are incredibly grateful for all their help and to all those who share our ambitious vision of the future of molecular biology, sticking with us as QuickGene's capabilities continue to grow.

The office is overflowing with creativity as we continue to plan better, faster and more intuitive ways to approach common problems and introducing biology to modern software. Needless to say, 2010 will be packed with some of the most innovative updates to date!

Note that with today's release of the first commercially available version of QuickGene, it is also the last day to get licenses at a 25% discount. Hurry to the online store or send us an email if you haven't done so yet! As usual, you can see the complete list of changes and improvements since last week's 0.9 beta update attached below.

The feeling of excitement and anticipation is palpable, but today is reserved for some well-deserved partying. If you're in the neighborhood of the Kruyt building in Utrecht, we invite you to come by our office for some cake! We hope you enjoy using QuickGene as much as we enjoy building it and hope to continue our collaboration in 2010!

All the best,
Eric Lammertsma and the rest of the team

Changes

• The in-line statistics calculator is completely restyled. It is faster, can be minimized and can be moved anywhere to stay out of the way of your sequence.


• Enzymes in the enzyme manager can now quickly be found by typing the first few letters.


• Which translation frames are displayed is now stored for each sequence instead of as a global setting.


• Features are now shown with the exact color you select, instead of in a pastel tint, making similar colors more distinct.


• Creating PDF files from maps displays feature colors as solid colors instead of as a semitransparent mesh.


• Feature names in sequences are now larger and more legible on Mac.


• Improved system integration for Windows Vista and Windows 7.


• Fixed: The in-line statistics calculator is no longer cut off in short sequences.


• Fixed: Search results display correctly in the map views.


• Fixed: Search results now report the correct position in their names.


• Fixed: Importing or pasting from the clipboard no longer corrupts the complement strand.


• Fixed: Removing enzymes from enzyme lists no longer results in those enzymes still being displayed until the list is refreshed.


• Fixed: The cursor position and selection in the status bar now correctly display the current setting instead of defaulting back to base pairs when opening a file.


• Fixed: QuickGene now displays correctly on computers with non-standard DPI settings.


• Fixed: Clicking on enzymes in the circular map now always places the cursor at the cleavage site.

QuickGene Beta 0.9 - Setting the Stage for 1.0

One week before QuickGene's graduation from beta, launching it into the world for all to use, we're setting the stage with the final beta update. Update 0.9 kicks off the new year with a tweak or two and smooths out a handful of little wrinkles. With this update, it is now possible to activate your copy of QuickGene using a pre-launch license key.

This also means that there is only one week left to take advantage of our deal for beta testers. If you haven't done so yet, hurry over to the store to grab a license for yourself or your lab at a 25% discount!

The modest list of changes in this update is below:

Changes

• Added flexibility to the feature creation dialog when handling bookmarks.


• Fixed several small glitches in the map view.


• Fixed a problem where the view options panel was blank after creating a new project.


• Fixed a problem with whitespace removal when copying and pasting sequences which corrupted the complement strand.


• Fixed the feature creation dialog not being displayed if the sequence was not selected.

QuickGene Beta 0.8 Delivers User Requested Features and Changes

As promised, in this update we have focused exclusively on features and changes that have been requested often or by paying customers. In particular, by popular request, we have made navigating to specific positions or selecting regions in a sequence incredibly easy. Simply click on the numbered position, displayed below the sequence, and enter a number or a range in either base pairs or amino acids in any reading frame! Furthermore, the size of a selection can also be changed easily by editing the size attribute. This tool makes exact sequence navigation extremely fast and intuitive.



Highlighting of identical enzyme cleavage sites in maps was introduced in the previous update, but naturally this is also useful when editing your sequence. Therefore, we have added the same restriction site highlighting in the feature bar, next to the scroll bar. This allows you to view all instances of the selected restriction enzyme's cleavage sites without the need to switch to the map, making restriction mapping even easier.



Usability has also been improved by allowing more view customization. For example, the in-line statistics calculator, enzyme information and reading frame highlighting can now be toggled on and off easily. As usual, we fixed any errors people have encountered and this remains our top priority.

Notably, there will probably not be a version 0.9 before the release of version 1.0 and the end of the beta on January 15th. This also means that there is only one month left to grab QuickGene at a 25% discount! With the holidays in between, it will be gone before you know it, so don't miss out!

You can check out the full list of changes below:

New features

• Cursor position and selected range in statusbar are now editable in both base pair and amino acid positions.


• When hovering over an enzyme in the sequence or map view, the feature bar highlights all cleavage site occurences.


• Added support for importing DNA Strider 1.4 files.


• Added easily accessible "copy reverse complement" function when right-clicking on a sequence.


• Added checkboxes to the view options to allow disabling several display features, such as selection statistics, enzyme information and reading frame highlighting.

Changes

• Double clicking a feature in the map view now opens the feature edit dialog.


• Added support for Shift+clicking on features in the sequence view to include them in existing selections.


• Tweaked and renamed numerous interface elements and features to be more intuitive or easier to access.


• Fixed a rare problem in which the sequence would be drawn over enzyme information.


• Fixed Mac menu items mistakenly displaying keyboard shortcuts as "Ctrl+..." instead of "Cmd+..."


• Fixed rare font problems on Windows computers, resulting in translations and/or the sequence being displayed as nonsense.


• Fixed a problem where clicking features in the editor did not select the sequence correctly.


• Fixed a problem with reversed features so that they are now copied and pasted correctly.


• Fixed the feature creation window where pressing Enter would ignore the properties specified by the user.

QuickGene Beta 0.7 Brings You an In-line Calculator and Cleaner Maps

The latest QuickGene update, released today, bumps the version number up to 0.7 and brings with it the customary list of improvements and additions. Most notably, we have introduced an in-line calculator that calculates the molecular weight and melting temperature of any selected sequence. This happens on-the-fly, while you make the selection, helping you create the perfect primers! This is our first step toward primer design and PCR tools and you can certainly expect more to come.



In the meantime, we continue to improve the cloning tools and have made some major changes to the maps. The design is cleaner and more organized and label placement is much more logical. Furthermore, we have added the often requested enzyme highlighting function. Holding the mouse over any enzyme in a map now not only displays its information but also highlights all other occurrences of that enzyme's recognition site. The first speed optimizations have also been added, making map navigation smoother and more useful. We will continue to add speed optimizations in the coming updates.

The full list of changes in the 0.7 update is as follows:

New features

• Replaced design for the linear and circular maps, reducing clutter and improving readability and performance.


• Added highlighting of all occurrences of a restriction enzyme cleavage site when hovering the mouse pointer over one in the maps.


• Added a quick overview of statistical information, including melting temperature and molecular weight, when selecting a range in the editor.


• Added cursor position indicator to map views.

Changes

• Improved stability on Windows 7.


• Improved integration into Mac OS X.


• Changed label positioning in maps to be more logical.


• Added first speed optimizations to the map view.


• Added file-type support and opening QuickGene from Finder for Mac OS X.


• Fixed QuickGene being killed when pressing Command + Q on Mac OS X. This now shuts it down neatly, requesting to save if unsaved changes are present.


• Fixed the cursor being placed incorrectly when clicking on an enzyme in a sequence. It is now placed at the cleavage site.


• Fixed freezes when sorting features in the sidebar.


• Fixed the problem in Mac OS X when opening a project from Finder would cause an open project to be closed.


• Fixed the problem that translation view options were not remembered correctly between sessions.

QuickGene Beta 0.6 - Even More Reliable and Supporting Windows 7

Currently, we're focusing on the stability and reliability of QuickGene. When designing your cloning strategy, you want to know the program you're using isn't going to fall apart and crash moments before you save your work. While we're making good on our promise to be the most reliable program out there, we've already built a backup system to make sure that a crash doesn't mean starting from scratch. If an essential component of QuickGene fails, a safety net is in place that will perform a last-second save of your project. The next time you start QuickGene, it will present you with the backup, letting you get back to work, throw it away or save it for later.

Of course, the ultimate goal is for no one to experience that life-saving backup function. In update 0.6.0, we've ensured Windows 7 compatibility and hammered out a handful of bugs. In particular, file and project support has been vastly improved, yet again, and you'll have the pleasure of knowing it can handle huge projects with thousands of features, millions of bases long. If you have a GenBank file QuickGene can't handle, we want to know about it! You can look forward to support for more file-types in the future too.

As usual, the full list of changes in QuickGene 0.6 is below.

New features

• Added compatibility for Windows 7.


• Feature names now appear within features in the sequence view, and in a tooltip when hovering the mouse pointer over them.


• The "Go to base pair" function now allows selection of a range.


• Creating features now supports complex features and ranges. (One feature's position may be specified as "100-200,250-300" which will be displayed as a feature from bp100-300. Later, this will be displayed in more detail, clearly showing gaps.)

Changes

• Improved feedback panel in the welcome screen. (Please revote on items that have no yellow stars)


• Fixed crashes when importing sequences into a project.


• Fixed unnecessary "problem" messages regarding unknown or misplaced keywords when opening GenBank files.


• Fixed crashes when rapidly sorting enzyme lists in the Enzyme Manager and Statistics tab.


• Fixed importing QuickGene project files (.qgproj) that would result in empty sequences.


• Fixed screenshot thumbnails in the feedback dialog being distorted.

Update Addresses Issues Caused by Java 1.6 Update 15

Sun and Oracle would do well to test and repair their updates as rigorously as we do! Last week, an update was released for Java, the technology on which QuickGene is based. That update contains a major flaw for Windows users, which prevents QuickGene (or any other Java program) from accessing certain essential information it has stored in the registry. This causes QuickGene 0.5 to crash while starting up.

Unfortunately, this update was released at nearly the same time as the QuickGene update, resulting in a number of computers containing the both the new Java version and QuickGene 0.5. Per chance, none of the four PCs in the office had the update, which caused the problem to go unnoticed until we updated our QuickGene installations at home and received reports from beta testers about mysterious crashes. Of course, we got to work on the problem immediately and, two hours later, we released a new update to version 0.5.1. This temporarily circumvented the problem, avoiding further crashes and allowing people to run QuickGene once again, despite the errors in Java.

Today, we have released an improved version which entirely avoids the current registry access problems currently present in Java. All Windows users should check for updates via the "Help" menu or download and install the latest version (currently 0.5.2) as soon as possible.

QuickGene Beta 0.5 Adds Easy Navigation to Vector Maps

A great deal of work went into the step to QuickGene's update to 0.5, including a complete overhaul of the way in which maps are displayed. Users might recognize the navigation methods from regular map services such as Google Maps, in which smooth scrolling and zooming with intuitive mouse controls were a refreshing innovation. We've adopted this natural feeling navigation method for use in genetic maps, making QuickGene's map controls the most intuitive in existence!

Standard functions such as printing, saving images, toggling the display different elements and many other enhancements have also been added to the map view. This view replaces the previously available linear and circular views, further enhancing the clean, straight-forward interface QuickGene aims for.

One of the most popular requests we receive is the ability to choose which buffers to display, when more than one is available. As always, your wish is our command! Users may now also specify their preferred enzyme supplier in the Enzyme Manager, which will then always display those buffers when available for any given restriction enzyme. This includes the buffers displayed anywhere the Enzyme Manager as well as in tool-tips shown when hovering the mouse over restriction sites in a sequence or map.

Full support for saving files to the GenBank format has also been completed, allowing for extended interaction between QuickGene and any other software tools you use. Furthermore, QuickGene can now open even more file-types and even attempts to recognize sequences in files it doesn't recognize!

We hope you enjoy all the improvements and feel free to give us your opinion.

The full list of changes is as follows:

New features

• Sequence maps have been completely rebuilt and now include:
  
  
  
  • More intuitive navigation using mouse controls
  
  
  • New navigation controls and a mini-map
  
  
  • Ability to print maps and to save maps as image files
  
  
  • Merged linear and circular maps into a single view
  
  
  • Added view options to select topology and visibility of features, enzymes and rulers
  
  
  • Improved map rulers
  
  
  • Improved display speed
• Replaced "Sequence Editor" shelf-menu with more intuitive, view-dependent "View Options"


• Added colorized feature icons, indicating bookmark, feature or search result, including direction and strand, if applicable.


• Full GenBank support with additional support for QuickGene-specific information, such as colors, non-directional features and bookmarks.


• Added the option to select which enzyme producer appears first in tooltips and in the enzyme manager


• Added option to copy a selection as the top or bottom strand in either direction or as a translation in any frame.

Changes

• Added a warning dialog when saving in the Fasta format when data may be lost


• Increased flexibility of opening simple sequence files


• Improved loading speeds of enzyme lists


• Merged the "Sequence" and "Project" menus, introducing a new "Map" menu for newly introduced functionality


• Fixed certain ".seq" files occasionally not being recognized as valid sequences


• Fixed rare cases of missed enzyme cleavage sites with ambiguous, palindromic recognition sequences


• Fixed incorrect and inconsistent frames of translations


• Fixed display of bookmarks in the sequence editor


• Fixed available space in the status bar for base position and selection sizes


• Fixed base number of cursor position to be more logical


• Fixed printing sequence with single-letter translations


• Fixed printing sequence with features

Testing Period of QuickGene Extended Through Summer

Following all the great feedback we've been receiving, we would like to thank all our users for all their help and have decided to extend the test-period throughout the summer months! Thanks to you, QuickGene is growing rapidly and constantly becoming faster and more robust.

To extend the testing period of QuickGene, it needs to be updated to the latest version, 0.4.2, before July 1st!

You can do this easily by starting up QuickGene and, if it does not begin updating on it's own, selecting "Check for updates" in the help menu. If you have a version older than 0.3, you will need to download the newest installer from http://www.crimsonbase.com/download using the email address you signed up with. After installing, follow the same steps to perform the update. You can check which version you have by selecting "About QuickGene" in the help menu.

QuickGene Beta 0.4.1 Improves Large File Support

The newest update to QuickGene, which just rolled out a few minutes ago, brings with it many behind-the-scenes improvements. The small version number change, from 0.4.0 to 0.4.1, reflects the relatively small number of obvious differences. The first difference will be clear immediately upon opening QuickGene after the update. The welcome screen now allows every user to easily rate popular ideas, letting us know which items are high priority and allowing us to focus on these during development. Additionally, providing new ideas and feedback regarding problems or suggestions has become much easier.

Behind the scenes, and tucked in various corners of QuickGene, are some larger changes. Much focus has been placed on enhanced support for large files, as many users have noted that QuickGene handles files containing over five million bases with ease. We have expanded this support to include massive GenBank files, which may contain tens of thousands of annotated features, and increased performance and loading times. In general, file loading capabilities have also been tweaked for reliability. Drawing maps at these vast sizes is currently not functional, however we have a number of enhancements to the map view coming up soon!

Support for Mac OS X has also been broadened to include 10.4.x, so Tiger users no longer need to feel left out. Another much requested feature has been partially implemented, allowing selection of reading frames for translation as well as selecting single-letter translations. In a future update, annotated features may have a reading frame assigned to them, so that relevant translations can be shown locally, as opposed to throughout the entire sequence.

The full list of changes is as follows:

New features

• Added a rating system for popular feedback


• Added an option to view single letter translations


• Added an option to view only specific reading frames

Changes

• Broadened Mac OS X support to include 10.4.x


• Greatly enhanced performance for large files


• General improvements to file loading


• Improved support for malformed GenBank files


• Improved display of features next to the scroll bar


• Simplified feedback dialog


• Increased performance when scrolling


• Made general improvements to stability


• Fixed: Features are displayed in the correct order


• Fixed: Closing projects always returns to the welcome screen


• Fixed: Feature colors are saved correctly on Mac


• Fixed: Numerous mouse-related bugs in the sequence editor

The next major update will complete support for GenBank files, allowing for saving of sequences according to the exact NCBI specifications. Furthermore, the aforementioned enhancements to the graphic maps will be added, allowing for much more intuitive navigation and additional support for large files. As usual, you can expect a lot more changes soon!

QuickGene Beta 0.4 Released

Today, we're rolling out another major update which brings with it a list of new features and changes but, most notably, renewed support for Mac OS! Due to a broken development machine, we were unable to keep the Mac version updated and since the arrival of a replacement we've been hard at work, pushing QuickGene's Mac support back up to the most recent version. Mac users will therefore experience quite a difference and we'd love to hear what you think!

Naturally, the update brings more to the table than Mac-only news. The list of changes since QuickGene Beta 0.3 is one we're proud of, introducing much-needed features such as the long-awaited printing capabilities and many improvements to the search function. The full list is as follows:

New features

• Updated support for Mac OS X


• Sequence Printing


• Numerous search options


• Search results indicate strand and direction


• Amino acid seqence search

Changes

• More informative enzyme tooltips


• More intuitive searches and results


• Removed the need to specify search types


• Copying and pasting sequences includes features


• Creating screenshots for bug reports can be done at the press of a button


• Fixed: Sequence selection is not lost when interacting with enzymes or right-clicking


• Fixed: Sequence can be selected between restriction enzyme cleavage sites intuitively


• Many smaller repairs and user-requested changes

We're currently working on adding a number of essential functions such as the ability to save in the GenBank format and further expansion of search capabilities, as well as building more of the features you have been requesting. There are truly some great ideas coming in and we can't wait to get to work on them!

Mac Support and Update Preview

Don't despair! We certainly haven't forgotten our Mac users!

Mac support has been unfortunately delayed, as our development Mac had been sent in for repairs after the 0.2 update and was only recently declared officially deceased. We hope to have a replacement by next week, at which point the available updates can be edited for Mac compatibility and tested for release. We apologize for the inconvenience and we're well aware of the major changes that Mac's are missing out on.

Following this week's update, which featured user-requested changes and repairs, the next update is planned to include more major functionality enhancements. Currently, these include a complete overhaul of the search feature and implementation of the previously announced printing capability.

The search function is currently undergoing a major upgrade which will make it the most robust, intuitive search available in any sequence analysis software. Most importantly, it's smart and straight-forward, allowing users to easily find any sequence, restriction enzyme or translation without the need to tell QuickGene. Furthermore, many useful standard and unique search criteria can be specified when more control or specificity is required. We're confident that you'll be amazed how much more quickly you can zip through your projects, finding exactly what you need.

Although the announced sequence printing functionality is already working, its release has been delayed as we ensure compatibility with most printers. Once this is completed, it will be included in the next update and map printing will be soon to follow.

Development of QuickGene continues to steam forward and we're having a great time building it, reading your feedback and dreaming up new features. Stay tuned for the release notes of the next update to find out more about it!

QuickGene Beta Update 0.3.1 (PC only)

Update 0.3.1 for QuickGene was released this week, focusing strongly on user-feedback. We addressed a number of problems and made numerous changes to the interface and usability, making many features clearer and easier to access. Most notably, the search function received a small update, which is only a hint of things to come. It now searches both strands by default (the template strand and reverse complement) and will soon receive an update to set these parameters.

The bulk of work for this update has gone into repairs and modifications requested by users. These include the following list of changes:

• Statistics tab now has the option to display non-cutting enzymes.


• The general design has been improved. (Let us know what you think!)


• Restriction site searches are 20% faster.


• Translation readability has been improved.


• Stability and crash detection have been improved.


• Fixed: Searching now includes the reverse complement. (Configuration options will be included in the next update)


• Fixed: Nucleotide counts now update properly after editing the sequence.


• Fixed: GenBank file requirements have been relaxed. (QuickGene now still attempts to open GenBank files that do not adhere exactly to the GenBank specification)

Naturally, we are very committed to building what you need and have been working hard to do so. Keep sending us ideas for improvement and we'll continue adding them!

QuickGene Beta 0.3 Released

We're proud to announce that the next update, 0.3, is now available! Before you run to download it however, please note that if you already have QuickGene, the update will download automatically within the next week. You can also make it update itself now by clicking "Check for updates" in the help menu. If you don't have a copy of QuickGene, you can sign up to beta-test it for free. (We're currently in the process of simplifying this, so you can get your hands on it without waiting for a personal invitation from one of us.)

Version 0.3 boasts two big, new features and a battery of improvements. QuickGene is now faster, smaller and more stable! The first feature you may notice is the addition of in-line translations. Translations are displayed in all three frames of your sequence and, if you view the complement strand, reverse frames are shown, as well. Hovering the mouse over a line of translations highlights them, as well as the corresponding codons, providing a much clearer view. A translation manager has also been built to allow selection of alternate translation tables, easily accessed through the tools menu or by pressing F6.

The second obvious addition to QuickGene is the "Stats" tab, which offers statistics and extra information on the sequence currently in view. Most notably, this new tab contains the often-needed restriction table, which allows you to view how each individual enzyme interacts with your sequence. The table combines all the data you need, allowing you to quickly view unique cutters, fragment sizes, and graphical representations. Furthermore, this tab allows you to quickly edit the sequence's name, circular or linear form, description and notes as well as view nucleotide frequencies and GC-content.

As we continue to work on overall improvements, we're still eager to hear your ideas. Next up are expansion of the feature-types with more design options, expansion of search capabilities, printing functionality and Vector NTI database import. We're also eager to move on to bigger, future improvements such as full AB1-support with editing and alignment capabilities, primer design, contig assembly, and extremely streamlined cloning advice. There's plenty to do so let us know what your preferences are!

QuickGene Beta 0.2 Released

During the past two months of testing, a number of beta testers helped point out many areas in which QuickGene could be improved, and we've been happy to comply! We're very excited about how it's developing and now the newest beta version, 0.2, is available to download.

Most notably, the licensing problem has been fixed and this will be the last version you ever need to download as QuickGene now supports fully automatic updates. This means that all repairs and improvements we make will be downloaded and implemented by QuickGene itself on a weekly basis. That's one less thing for you to think about and constitutes the biggest change in the new version.

We've made many other changes as well, particularly in speed and stability. The complement strand has been added and translations are soon to follow. GenBank files are now recognized and all features therein will be recognized and loaded.

Registered users can login (using the e-mail address with which you registered) to gain access to the download page where the most current versions are available. If you're not currently registered, we encourage you to do so, as we're welcoming everyone and are eager to hear your suggestions for improvement!

We're actively working on adding the features that have been requested so far, so if you have any suggestions or additions, please don't hesitate to e-mail us or to use the feedback buttons in QuickGene. Thanks again for all the great feedback so far!

QuickGene Beta is Ready!

After nearly a year of planning and development, QuickGene is finally ready to be tested in the real world and we've sent invitations to all registered beta-testers. We're all extremely excited to show off our hard work and hope you enjoy taking it for a test-drive. This phase is important in that it helps us decide which features to build first, as we have too many ideas for improvement to get them all implemented at once.

However, we're also very enthusiastic to hear about your own suggestions! After all, scientists are a creative bunch who work on solving problems on a daily basis. To make this process easier, QuickGene contains methods to provide feedback and send us those suggestions directly from within the program. Don't worry about how minor or colossal your ideas are; receiving feedback is great motivation and puts a smile on all our faces.

As we are also a small team with just over 50 participating researchers, it's great to get to brainstorm with our testers, often resulting in innovative and efficient new ways to get work done in QuickGene. Corresponding through QuickGene or setting up a meeting at your lab is fun and productive, and we'd love to show you how enthusiastic, devoted and serious we are about making this the best and easiest program available in genetics!